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Engineered Nanoparticles Reported to Affect Iron Absorption
February 27, 2012By Ricardo Carvajal –
Researchers report that in vitro and in vivo experiments conducted with polystyrene nanoparticles indicate that nanoparticle exposure can disrupt iron transport in the gut, and may possibly disrupt absorption of other minerals, as well as vitamins. The in vivo experiments, which were conducted in chickens, further indicate that chronic exposure can result in remodeling of intestinal villi to increase surface area so as to increase absorption, thereby compensating for the disruption in nutrient transport. Chickens were chosen for the experiments in part because of similarities between their gastrointestinal tract and that of humans.
The significance of these findings may be difficult to assess until additional studies on the effects of nanoparticle exposure on the gut have been conducted. Nonetheless, they should be of interest to food ingredient developers, given the researchers’ observation that dietary particles in certain food additives have been thought to potentially have adverse health effects. The findings should also be of interest to drug developers, given the utility of nanoparticle carriers for drug delivery.
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- Most Favored Nation Drug Pricing Rule on Hold Awaiting Changes January 22, 2021
- FDA Continues Discussion of AI/ML Software Medical Devices January 21, 2021
- Proposed Changes to Short-Form Version of Safe Harbor Proposition 65 Warning January 20, 2021
- AMG v. FTC: A Moot Court-Worthy Conflict at the Supreme Court January 15, 2021
- Orange Book Modernization Act: Congress Largely Codifies FDA’s Existing Orange Book Practices, But Also Brings PTAB Decisions Into the Fold January 14, 2021
- Big Molecule Watch Blog
- Bloomberg BNA Health Care Blog
- Drug and Device Law Blog
- Eye on FDA
- FDA Matters
- Harvard Law Bill of Health
- IN VIVO Blog
- Internet Drug News.com
- Lachman Consultants Blog
- Medical Devices Today
- Orange Book Blog
- The Orange Book Insights Blog
- Pharma IQ
- Pharmalot
- SCOTUS Blog
- The Volokh Conspiracy
- WLF Legal Pulse
- Advertising and Promotion (Federal Trade Commission)
- Advertising and Promotion (OPDP)
- Animal Drugs and Feeds
- Biosimilars
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- cGMP Compliance
- Consumer Product Safety Commission
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- Cosmetics
- COVID19
- Current Affairs
- Dietary Supplements
- Drug Development
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- FDA News
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- Foods and Dietary Supplements
- Fraud and Abuse
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- Hatch-Waxman
- Health Care
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- Import/Export
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- Reimbursement
- Tissue Products
- Tobacco
- Uncategorized